The serum NF-κB and adiponectin levels in patients with acute pancreatitis

The serum NF-B and adiponectin levels in patients with acute pancreatitis A cute pancreatitis (AP) is a serious condition marked by sudden inflammation of the pancreas, which can result in significant complications and may necessitate intensive care.The disease is defined by an inflammatory response that causes swelling and bleeding in pancreatic tissue.In severe instances, it may lead to the necrosis of pancreatic tissue due to premature enzyme activation within the organ [1].It is often associated with gallstones and excessive alcohol consumption.AP starts with the initiation of the process of autodiges-tion, which leads to the pancreas digesting itself, resulting in damage to tissues through activation of enzymes.Clinically, AP can present in both mild and severe forms; the severe form carries a risk of developing systemic inflammatory response syndrome (SIRS) and multiple organ failure [2].Gallstones and chronic alcohol abuse account for approximately two-thirds of cases in the etiology of acute pancreatitis.Other common causes include the development of AP following endoscopic retrograde cholangiopancreatography Objectives: This study aimed to evaluate whether serum nuclear factor-kappa B (NF-B) and adiponectin levels can provide insight into disease progression and serve as potential biomarkers for predicting disease severity in patients with acute pancreatitis (AP).Methods: A total of 49 patients diagnosed with AP and admitted to the Emergency Department of Gaziosmanpaa Training and Research Hospital were enrolled.An age-matched control group of 49 healthy individuals without AP was also included.Serum levels of NF-B and adiponectin were measured and compared between groups.Results: Patients with AP exhibited significantly elevated serum NF-B levels and reduced adiponectin levels compared to the control group (both p<0.001).A strong negative correlation was observed between adiponectin and NF-B levels in the AP group (r=-0.865,p<0.05).Receiver operating characteristic (ROC) analysis determined the optimal cut-off value for adiponectin as 3.4, with a sensitivity and specificity of 1.000.The optimal cut-off for NF-B was 1.8, with a sensitivity of 1.000 and specificity of 0.96. Conclusion:The findings suggest that serum NF-B and adiponectin levels may be valuable biomarkers for assessing disease severity in AP.Their combined use or integration with existing scoring systems could enhance prognostic accuracy.Further experimental and clinical studies are necessary to evaluate the therapeutic potential of adiponectin and to validate these biomarkers for routine clinical use.