Oxidative [3+2] annulation of activated pyridines for the synthesis of indolizinyl sulfonyl fluorides: a class of important pharmacophores
A novel method for synthesizing valuable indolizine-functionalized sulfonyl fluorides has been developed through oxidative [3+2] annulation of activated pyridines and β-arylethenesulfonyl fluorides. This transformation features high efficiency, mild reaction conditions and readily accessible starting materials, and is transition-metal free. Consequently, this reaction holds significant promise in the field of medicinal chemistry and other related disciplines.
Authors
- Yiyong Huang (ORCID: https://orcid.org/0000-0001-6209-8304)
- Hanadi A. Katouah (ORCID: https://orcid.org/0000-0001-9044-2491)
- Eman Elsayed Fayad (ORCID: https://orcid.org/0000-0003-2916-0254)
- Hua‐Li Qin (ORCID: https://orcid.org/0000-0002-6609-0083)
- Sen Zhang (ORCID: https://orcid.org/0000-0002-1716-3741)
Institutions
- Taif University (SA)
- Wuhan University of Technology (CN)
- Umm al-Qura University (SA)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02186c
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taif University
- Wuhan University of Technology