Exploring the causal association between pre‐pregnancy obesity and pregnancy‐related complications, and mediating pathways of obesity on adverse pregnancy outcomes: Insights from Mendelian randomization analysis
Obesity does not directly affect all APOs. Insulin resistance, lipotoxicity, and inflammation mediate the causality between obesity and certain pregnancy-related conditions and may promote the prediction and prevention of specific APOs.
Authors
- Qiqi Ruan
- S.X. Liu (ORCID: https://orcid.org/0000-0002-0041-1745)
- Yuan Shi (ORCID: https://orcid.org/0000-0002-4571-4424)
- Zhuolin Dai
- Feng Chen (ORCID: https://orcid.org/0000-0003-3508-8834)
Institutions
- Chongqing Maternal and Child Health Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1002/ijgo.70314
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University