Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis in vivo and in vitro
The results of this study suggest that THC exerts anti-NASH effects by improving lipid levels, decreasing oxidative stress, attenuating inflammatory responses, and increasing the anti-apoptotic capacity of liver cells, and its efficacy is importantly associated with decreasing the expression of PPARG and improving the intestinal flora. THC is expected to be a potential therapeutic agent for NASH.
Authors
- Keyu Chen (ORCID: https://orcid.org/0000-0003-2365-9302)
- Yunyun Quan
- Jianbo Wang (ORCID: https://orcid.org/0009-0001-0487-7729)
- Jiali Ma
- Shuang Luo
- Yunten Liu
- Jiali Fu
- Zhichong Gao
- Wei Ping (ORCID: https://orcid.org/0000-0002-8852-6618)
- Yuying Yang (ORCID: https://orcid.org/0000-0002-9302-7629)
Institutions
- Southwest Medical University (CN)
- Chengdu University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.3389/fmicb.2025.1576221
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00