Mechanical tension-induced Dalrd3 elevation enhances osteogenic differentiation of bone suture stem cells by upregulating Id3 translation
These findings reveal a translational regulatory mechanism in SuSCs activated by mechanical tension and underscore the pivotal role of Dalrd3 in suture remodeling and bone formation. The insights provided by this study have the potential to guide targeted therapeutic strategies for optimizing distraction osteogenesis and other treatments for craniofacial deformities.
Authors
- Yang Cao (ORCID: https://orcid.org/0000-0002-0058-614X)
- Chongmai Zeng (ORCID: https://orcid.org/0000-0003-0325-6469)
- Yiwei Zhao (ORCID: https://orcid.org/0000-0003-3935-5637)
- Guoli Tian (ORCID: https://orcid.org/0000-0001-5069-5128)
- Zhicai Feng
- Jie Chen (ORCID: https://orcid.org/0000-0002-8295-6350)
Institutions
- Stomatology Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s13287-025-04380-9
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Fundamental Research Funds for the Central Universities
- Young Teacher Foundation of Sun Yat-sen University
- Basic and Applied Basic Research Foundation of Guangdong Province