Green Chemistry Approaches in Pharmaceutical Synthesis: Sustainable Methods for Drug Development

The Pharmaceutical Strategy for Europe addresses the environmental implications at all stages of the life cycle of pharmaceuticals, from design and production through use to disposal. In the last decade, “green chemistry” has transformed pharmaceuticals by promoting sustainability and reducing environmental impact. This review discusses the latest developments in green chemistry approaches, which are applied in drug design and production, including the concepts, innovative techniques, and methodologies. This review is notably built on over 80 documents and demonstrates the practical application of green chemistry principles in pharmaceutical synthesis, emphasizing successful implementation and the environmental benefits achieved. Therefore, this review discusses the positive changes brought by green chemistry to pharmaceutical production and highlights the need for further research in designing and manufacturing “greener” substances, as well as in pollution abatement.