Formulation Development of Gliclazide & Glipizide Nanoparticle: A Comparative Systematic Review

The use of nanoparticles (NPs) for the delivery of antidiabetic gliclazide and glipizide is elaborated in the systematic review of the literature. This systematic review presents a proper comparative examination of the development of nanoparticle formulations for gliclazide and glipizide, two sulphonyl urea medications used in the treatment of type 2 diabetes. Because of their potential to increase medication solubility, bioavailability, and grant sustained release, nanoparticle-based drug delivery systems have received a lot of interest. The review gives an overview of the pharmacological characteristics, mechanism of action, and therapeutic applications of gliclazide and glipizide. It then digs into the formulation creation of nanoparticles for these medications, detailing the materials, origin processes, and characterization techniques employed in the investigations.