Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection
This study demonstrates that GFAP mAb inhibits astrogliosis and glial-glial activation, exerting neuroprotection through the inhibition of inflammation and pyroptosis. The findings suggest that targeting GFAP represents a promising immunotherapeutic strategy for glaucoma treatment.
Authors
- Kristian Nzogang Fomo
- Franz H. Grus
- Chaoqiang Guan
- Linglin Zhang (ORCID: https://orcid.org/0000-0002-1432-6082)
- Norbert Pfeiffer
- Jie Yang (ORCID: https://orcid.org/0000-0002-6833-2680)
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s12974-025-03482-8
- Citations
- 3
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz