Chromium(II)-Catalyzed Decarboxylative Alkyl Acylation under Visible Light Irradiation
By utilizing the stability of metal-ligand coordination and the instability of the metal-to-ligand charge transfer excited state to dissociate the ligand, the first chromium(II) decarboxylative alkyl acylation reaction under visible light irradiation is herein reported. The reaction uses α-keto acids as acyl radical precursors to react with alkyl radicals, without the need for additional photosensitizers or other additives. The elegant reaction exhibits a wide scope across α-keto acids, radical precursors, and alkanes with moderate to good yields.
Authors
- Hongyu Hou
- Xiaoning Guo (ORCID: https://orcid.org/0000-0001-7626-1539)
- Chen‐Ho Tung (ORCID: https://orcid.org/0000-0001-9999-9755)
- Jixin Yu
- Yuanyuan Cheng (ORCID: https://orcid.org/0000-0002-4749-3389)
- Li‐Zhu Wu (ORCID: https://orcid.org/0000-0002-5561-9922)
- Liang Ge (ORCID: https://orcid.org/0000-0002-7371-2039)
- Feng‐Xing Li
- Yu Liu (ORCID: https://orcid.org/0000-0003-4555-8238)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
- Hui‐Lan Hu
Institutions
- Chinese Academy of Sciences (CN)
- Technical Institute of Physics and Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c01930
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China