Thermolides D and E: Total Synthesis and Stereochemical Revision
Using stereochemical insights and synthetic chemistry principles, we successfully achieved the total synthesis of two diastereomers of thermolide D, as well as the proposed structure of thermolide E. By comparing their NMR spectra and demonstrating coelution of the synthetic and natural products on a semipreparative HPLC column, we confirmed the correct structures of thermolides D and E. Additionally, the stereochemical approach used in this study provides a reliable framework for future structural determinations of fungal-derived polyketides.
Authors
- Yian Guo (ORCID: https://orcid.org/0000-0002-0341-6816)
- Feipeng Han
- Chenqi Wang
- Wenquan Peng
- Atsushi Minami (ORCID: https://orcid.org/0000-0002-4183-0268)
- Hideaki Oikawa (ORCID: https://orcid.org/0000-0002-6947-3397)
- Tao Ye (ORCID: https://orcid.org/0000-0002-2780-9761)
- Junyang Liu (ORCID: https://orcid.org/0000-0002-4622-5200)
Institutions
- Tokyo Institute of Technology (JP)
- Hokkaido University (JP)
- Lifetech Scientific (China) (CN)
- Peking University Shenzhen Hospital (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c01326
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Department of Education of Guangdong Province
- Japan Society for the Promotion of Science