<i>Bordetella pertussis</i> exhibits genomic diversity within patients and laboratory culture
The whooping cough-causing bacterium <i>Bordetella pertussis</i> can alter its genetic structure while conserving areas essential for vaccine efficacy. By examining <i>B. pertussis</i> from infected patients, we demonstrate the significance of reducing laboratory manipulation of bacteria to maintain reliable monitoring data from laboratory cultures. Public health officials can use these data to develop efficient disease control tactics and better understand <i>B. pertussis</i>'s adaptability. This study highlights the importance of immunizations and the necessity of thorough genetic surveillance in the fight against this chronic and avoidable respiratory illness.
Authors
- Paula M. Snippes Vagnone
- Emily A. Travanty
- Daniel Kurien
- Hyun Jeong Ju (ORCID: https://orcid.org/0000-0003-2711-3112)
- Tami H. Skoff
- Yvette Unoarumhi (ORCID: https://orcid.org/0000-0001-9088-0360)
- Lucia C. Pawloski
- Emilie Bouda (ORCID: https://orcid.org/0000-0002-0327-1557)
- D. Santoro
- Matthew Cole (ORCID: https://orcid.org/0000-0002-9205-9055)
- Sarah Nobles (ORCID: https://orcid.org/0000-0003-1467-894X)
- M. Lucia Tondella (ORCID: https://orcid.org/0000-0002-4759-2985)
- Pamela K. Cassiday (ORCID: https://orcid.org/0000-0002-5845-676X)
- Michael R. Weigand (ORCID: https://orcid.org/0000-0002-7278-0160)
- Diego M. Morales (ORCID: https://orcid.org/0000-0001-6672-9046)
- Kevin J. Mitchell (ORCID: https://orcid.org/0000-0002-3433-4530)
- Margaret M. Williams (ORCID: https://orcid.org/0000-0003-3168-1286)
- Heather Fueston (ORCID: https://orcid.org/0009-0004-1434-3490)
- Yajun Peng (ORCID: https://orcid.org/0000-0001-6455-2873)
- John E. Heuser (ORCID: https://orcid.org/0000-0002-3593-8846)
- Martin Bentz
Institutions
- New York State Department of Health (US)
- Colorado Department of Public Health and Environment (US)
- National Center for Immunization and Respiratory Diseases (US)
- Oregon State Hospital (US)
- Response Biomedical (Canada) (CA)
- Connecticut Department of Public Health (US)
- Minnesota Department of Health (US)
Publication Details
- Journal
- mSystems
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1128/msystems.01717-24
- Citations
- 1
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.18