Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment
Our findings suggest that liposomal encapsulation of ripasudil supports enhanced bioavailability and effectiveness of the drug, presenting a promising innovative therapeutic approach for the treatment of proliferative vitreoretinopathy.
Authors
- Tomohito Tanihara
- Keijiro Ishikawa (ORCID: https://orcid.org/0000-0002-4590-4471)
- Wei Tan (ORCID: https://orcid.org/0000-0002-3854-7576)
- Shintaro Nakao (ORCID: https://orcid.org/0000-0003-4200-0052)
- Kaita Otsuki
- Shigehiro Ohdo (ORCID: https://orcid.org/0000-0003-4795-9764)
- Tomoyuki Isobe
- K. Mori (ORCID: https://orcid.org/0000-0002-1872-5363)
- Ram Kannan (ORCID: https://orcid.org/0000-0002-1583-3414)
- Yuya Yoshida (ORCID: https://orcid.org/0000-0003-2394-9748)
- Iori Wada
- Shigeo Yoshida (ORCID: https://orcid.org/0000-0003-1049-8909)
- Kouta Mayanagi
- Kengo Hamamura (ORCID: https://orcid.org/0000-0001-9146-8554)
- Kohei Kiyohara (ORCID: https://orcid.org/0009-0002-9106-0131)
- Naoya Matsunaga (ORCID: https://orcid.org/0000-0002-0004-4535)
- Kosuke Oyama (ORCID: https://orcid.org/0009-0004-7821-5236)
- Yuma Terada
- Hiroshi Kikuchi
- Rui Ji (ORCID: https://orcid.org/0009-0009-3709-1149)
- Yosuke Fukuda (ORCID: https://orcid.org/0000-0002-0201-8541)
- Koh-Hei Sonoda (ORCID: https://orcid.org/0000-0002-9819-5509)
- Ryotaro Tsukamoto
Institutions
- Kurume University (JP)
- Kyushu University (JP)
- Juntendo University (JP)
- Kowa (Japan) (JP)
- Doheny Eye Institute (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1167/iovs.66.6.56
- Citations
- 2
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Japan Agency for Medical Research and Development
- National Institutes of Health
- Japan Society for the Promotion of Science