RIPK3-Mediated Necroptosis Drives Macrophage Infiltration and Corneal Neovascularization After Alkali Burn
This study revealed that RIPK3-mediated necroptosis drives macrophage inflammation and CoNV. Targeting RIPK3 could effectively suppress these responses by inhibiting the MLKL/FGF2 pathway, making it a promising therapeutic strategy for corneal AB.
Authors
- Yiming Ye (ORCID: https://orcid.org/0000-0001-7737-6100)
- Guangyi Huang (ORCID: https://orcid.org/0000-0003-2503-2044)
- Qianqian Lan (ORCID: https://orcid.org/0000-0001-8917-6659)
- Fan Xu (ORCID: https://orcid.org/0000-0002-1504-2356)
- Xiaojia Huang (ORCID: https://orcid.org/0000-0002-1641-1205)
- Yuchen Zhou (ORCID: https://orcid.org/0000-0003-2290-066X)
- Hui Huang
- Fen Tang (ORCID: https://orcid.org/0000-0001-9762-5231)
- Qi Chen (ORCID: https://orcid.org/0000-0001-6353-9589)
- Yue Li (ORCID: https://orcid.org/0000-0001-8198-9911)
- Li Jiang (ORCID: https://orcid.org/0000-0002-4422-567X)
- Ningning Tang (ORCID: https://orcid.org/0000-0002-5804-0369)
- Wenjing He
- Boyu Yang (ORCID: https://orcid.org/0000-0003-0302-836X)
- Wen Hu
Institutions
- Sun Yat-sen University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1167/iovs.66.6.54
- Citations
- 4
- Primary Topic
- Burn Injury Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province