CHD7 regulates definitive endodermal and mesodermal development from human embryonic stem cells
CHD7 is critical for DE and mesodermal development from hESCs. Our results provide new insights into the mechanisms by which CHD7 mutations cause multiple congenital anomalies.
Authors
- Laijun Lai (ORCID: https://orcid.org/0000-0002-4581-7642)
- Shikun Wang (ORCID: https://orcid.org/0000-0002-0282-878X)
- Kuan Chen Lai
- Jianqing Zheng
- Jin Zhao (ORCID: https://orcid.org/0000-0003-1442-6873)
- Rong Hu (ORCID: https://orcid.org/0000-0003-2998-064X)
- Christopher Stoddard
Institutions
- University of Connecticut (US)
- UConn Health (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s13287-025-04437-9
- Citations
- 3
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- University of Connecticut
- National Institutes of Health