Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification
This study identified a promising platform for understanding intrinsic tumor heterogeneity, which could offer new insights into the intricate molecular mechanisms of BLCA. Targeted therapy against BEXO2 may improve the prognosis of BLCA patients by regulating mitochondria-related metabolic disorders.
Authors
- Run Shi (ORCID: https://orcid.org/0000-0003-4667-4812)
- Xiaojuan Tang
- Zhaokai Zhou (ORCID: https://orcid.org/0000-0001-6628-3750)
- Zhengrui Li (ORCID: https://orcid.org/0000-0003-4923-0088)
- Shuai Yang (ORCID: https://orcid.org/0009-0000-7271-4182)
- Qi Li (ORCID: https://orcid.org/0000-0001-7380-8703)
- Zhan Wang (ORCID: https://orcid.org/0000-0003-0955-5822)
- Ruizhi Wang (ORCID: https://orcid.org/0000-0003-4768-414X)
- Kui Liu (ORCID: https://orcid.org/0000-0002-7493-2244)
Institutions
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Jiangsu Province Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s12967-025-06682-1
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04