Allogenic Transplantation of RPE Strips Lacking MHC Class II Can Avoid Rejection in Nonhuman Primate Eyes
Allogeneic transplantation of CIITA-/- RPE strips may reduce rejection risk in RPE-ablated disease model eyes, suggesting potential clinical benefits of MHC class II-deficient RPE grafts, particularly for diseases with inflammatory pathology.
Authors
- Noriko Sakai (ORCID: https://orcid.org/0000-0001-6106-7186)
- Masaaki Ishida
- Masayo Takahashi (ORCID: https://orcid.org/0000-0003-1836-6484)
- Michiko Mandai (ORCID: https://orcid.org/0000-0001-9174-2664)
- Mineo Kondo (ORCID: https://orcid.org/0000-0003-4569-1792)
- Sunao Sugita (ORCID: https://orcid.org/0000-0001-5271-4302)
- Satoshi Yokota (ORCID: https://orcid.org/0000-0002-3727-7279)
- Yasuo Kurimoto
- Naoko Hayashi
- Masashi Fujihara
- Mitsuhiro Nishida (ORCID: https://orcid.org/0000-0003-2016-3598)
- Atsuta Ozaki (ORCID: https://orcid.org/0000-0002-2359-5604)
- Takashi Shiina (ORCID: https://orcid.org/0000-0002-2067-6708)
- Kyoko Iseki
- Shinichiro ITO (ORCID: https://orcid.org/0000-0001-7275-140X)
Institutions
- Tokai University (JP)
- Mie University (JP)
- RIKEN (JP)
- RIKEN Center for Biosystems Dynamics Research (JP)
- Miyata Eye Hospital (JP)
- University of Toyama (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1167/iovs.66.6.53
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84