Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in <i>Aspergillus fumigatus</i>–Induced Fungal Keratitis
Overall, GSDME played a crucial role in pyroptosis during corneal inflammation. By modulating IL-1β release during pyroptosis, GSDME had a significant impact on the host immune response in FK. This process could be inhibited by blocking the ROS/casp-3/GSDME pathway, potentially offering a novel treatment option for reducing corneal opacity in FK.
Authors
- Qiang Xu (ORCID: https://orcid.org/0000-0002-3530-9855)
- Cheng-Ye Che
- Shasha Xue
- Mengzhu Liu
- Ji Eun Lee (ORCID: https://orcid.org/0000-0002-4927-2854)
- Jintao Sun
- Shiqi Song
- Xiaoyan Sun (ORCID: https://orcid.org/0000-0002-4317-6888)
- Jingze Kan
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Pusan National University (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1167/iovs.66.6.52
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province