Examining the Feasibility of Prolonged Beta-Hydroxybutyrate-Containing Supplement Drink Consumption in Adults with Type 2 Diabetes: A Randomized Controlled Pilot Trial
This remote pilot trial demonstrated mixed feasibility results. Recruitment, trial procedures, and data availability were strong but there was relatively high drop-out in the ketone group due to GI issues and taste. However, individuals who tolerated the supplement had good compliance over 90 days and there appeared to be evidence for glucose-lowering efficacy.
Authors
- Jonathan P. Little (ORCID: https://orcid.org/0000-0002-9796-2008)
- Bárbara Oliveira (ORCID: https://orcid.org/0000-0002-3270-5780)
- Jaime Tortoriello (ORCID: https://orcid.org/0000-0002-1597-7645)
- Kaja Falkenhain (ORCID: https://orcid.org/0000-0002-3240-964X)
- Kenneth Michael Madden (ORCID: https://orcid.org/0000-0003-4367-557X)
- Alexis Marcotte‐Chénard (ORCID: https://orcid.org/0000-0001-7594-5330)
- Joel Singer (ORCID: https://orcid.org/0000-0003-4936-4086)
- Kara Crampton
- Tori Bouck
Institutions
- Pennington Biomedical Research Center (US)
- University of British Columbia (CA)
- Okanagan University College (CA)
Publication Details
- Journal
- Journal of the American Nutrition Association
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1080/27697061.2025.2518116
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Michael Smith Health Research BC
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé