Targeted epicardial pulsed field ablation of atrial ganglionated plexi: Electrophysiological and histologic analysis in pigs
Targeted anatomically and high-frequency stimulation-guided epicardial PFA delivery to GP sites induces acute GP damage, prolongs aERP, and reduces AF inducibility and AF duration while preserving surrounding neuronal, myocardial, and vascular structures.
Authors
- Barry O’Brien (ORCID: https://orcid.org/0000-0001-5893-4672)
- Sevasti‐Maria Chaldoupi (ORCID: https://orcid.org/0000-0003-3938-6193)
- Julie Norup Hertel
- Sarah Dalgas Nissen (ORCID: https://orcid.org/0000-0001-8598-7147)
- Bart Maesen (ORCID: https://orcid.org/0000-0001-8622-1450)
- Thomas Jespersen (ORCID: https://orcid.org/0000-0001-6575-360X)
- Kezia Jerltorp (ORCID: https://orcid.org/0009-0009-0046-8731)
- Arnela Saljic (ORCID: https://orcid.org/0000-0001-8910-0902)
- B J M Hermans (ORCID: https://orcid.org/0000-0001-7780-4427)
- Jonas L. Isaksen (ORCID: https://orcid.org/0000-0003-3227-1131)
- Charles Ye
- Dominik Linz (ORCID: https://orcid.org/0000-0003-4893-0824)
- Lars Lindberg (ORCID: https://orcid.org/0000-0002-2246-2826)
- Luca Aerts (ORCID: https://orcid.org/0000-0003-0360-1824)
- K. P. Coffey (ORCID: https://orcid.org/0000-0002-9581-5522)
- Alisha Niskala
- John Reilly (ORCID: https://orcid.org/0009-0009-2061-8776)
- Mélodie J. Schneider (ORCID: https://orcid.org/0000-0001-8739-8223)
Institutions
- University of Copenhagen (DK)
- Maastricht University Medical Centre (NL)
- South Australian Health and Medical Research Institute (AU)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1016/j.hrthm.2025.06.016
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39