Protective Effects of Melatonin Against PM2.5-Induced Lung Damage
Melatonin may protect the lungs from PM2.5-induced damage by activating the Nrf2/HO-1 signaling pathway and reducing iNOS and TNF-α production. When applied to lung epithelial cells, melatonin inhibits EMT and lessens fibrosis. To further understand how melatonin protects individuals PM2.5-induced lung injury, the authors suggest conducting more human trials.
Authors
- İmran Özdemir (ORCID: https://orcid.org/0009-0002-8840-9363)
- Cemal Cingi (ORCID: https://orcid.org/0000-0003-3934-5092)
- Dilek Burukoğlu Dönmez (ORCID: https://orcid.org/0000-0002-6454-4424)
- Nuray Bayar Muluk (ORCID: https://orcid.org/0000-0003-3602-9289)
- Menekşe Karahan (ORCID: https://orcid.org/0000-0002-1114-4478)
Institutions
- Üsküdar University (TR)
- Biruni University (TR)
- Kırıkkale University (TR)
- Eskişehir Osmangazi University (TR)
Publication Details
- Journal
- Journal of Craniofacial Surgery
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1097/scs.0000000000011556
- Citations
- 1
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.20