Culturally related risk and protective factors for alcohol and marijuana use among Latinx college students

College students indicate high use of alcohol and marijuana; cultural influences may affect substance use. This study assessed the associations between alcohol and marijuana past 30-day use, and microaggressions, acculturation, and familism among Latinx college students. Participants (<i>n</i> = 484) completed measures, and structural equation modeling was used to yield results. Findings suggested that microaggressions were a risk factor for alcohol use, (<i>B</i> = -1.29, <i>p</i> = .007) while acculturation was a risk factor for marijuana use (<i>B</i> = 1.06, <i>p</i> = .011). No other statistically significant associations with alcohol or marijuana past 30-day use were observed. Culturally based prevention and intervention efforts appear warranted.