Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism
The unveiled organ crosstalks provide new insights into the metabolism-disrupting properties, hepatotoxicity, and reproductive toxicity of PFOS, which may facilitate the development of molecule-, metabolite-, and microbe-based strategies for PFOS-induced metabolic diseases and reproductive disorders.
Authors
- Huihui An
- Qing Chen (ORCID: https://orcid.org/0000-0003-4108-7977)
- Haonan Cui
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-7223-5234)
- Wei Huang (ORCID: https://orcid.org/0000-0003-3570-5556)
- Hong Guo (ORCID: https://orcid.org/0000-0002-5997-5086)
- Yang Wang (ORCID: https://orcid.org/0000-0003-4004-5353)
- Jia Cao (ORCID: https://orcid.org/0000-0001-7209-2993)
- Shijun He (ORCID: https://orcid.org/0000-0002-9475-8394)
- Jinyi Liu (ORCID: https://orcid.org/0000-0003-1803-7752)
- Lin Ao (ORCID: https://orcid.org/0000-0002-7788-6298)
- Peng Zou (ORCID: https://orcid.org/0000-0001-9255-6986)
- Xi Ling (ORCID: https://orcid.org/0009-0007-7175-4255)
Institutions
- Guangdong University of Technology (CN)
- Army Medical University (CN)
- Chongqing University (CN)
- Jinan University (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1016/j.jare.2025.06.037
- Citations
- 2
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 1.72