Hepatocellular Carcinoma in Cystic Fibrosis Liver Disease

Cystic fibrosis, traditionally considered an infrequent childhood disease, has increased in incidence due to advances in screening, and therapies fortunately have advanced leading to increased survival rates. Cystic fibrosis liver disease (CFLD) is well-described in the pediatric population; however, with increased life expectancy rates, a second wave has been observed in adults and represents the third most common cause of death. Although complications of portal hypertension have been described in setting of CFLD, the development of hepatocellular carcinoma is an extremely rare event. We present a patient with CFLD who developed hepatocellular carcinoma that was successfully treated with microwave ablation.