Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health
Our study provides longitudinal insights into how genetic and environmental factors shape human metabolic profiles, revealing unique and stable individual metabolic profiles. Plasma proteins emerged as key indicators for capturing the variability in human metabolism and assessing metabolic risks. These findings offer valuable tools for personalized medicine and the development of diagnostics for metabolic diseases.
Authors
- Fredrik Edfors (ORCID: https://orcid.org/0000-0002-0017-7987)
- Göran M.L. Bergström (ORCID: https://orcid.org/0000-0003-4289-5722)
- Wen Zhong (ORCID: https://orcid.org/0000-0002-7422-6104)
- Mathias Uhlén (ORCID: https://orcid.org/0000-0002-4858-8056)
- Alberto Zenere (ORCID: https://orcid.org/0000-0001-5791-7686)
- Jing Wang (ORCID: https://orcid.org/0000-0002-7566-1212)
- Xingyue Wang (ORCID: https://orcid.org/0000-0002-4960-5882)
Institutions
- Linköping University (SE)
- Sahlgrenska University Hospital (SE)
- Region Västra Götaland (SE)
- KTH Royal Institute of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s13073-025-01492-y
- Citations
- 3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Linköpings Universitet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet