Dysmorphic neurons with ultralow intrinsic excitability are paradoxically hyperexcitable in neural network in a mouse model of focal cortical dysplasia type <scp>II</scp>
Together, these findings indicate that excessive excitatory synaptic inputs prevail over reduced intrinsic excitability in dysmorphic neurons, leading to hyperexcitability in FCDII. Furthermore, they strongly suggest GABA<sub>B</sub> receptors as a potential therapeutic target for FCDII.
Authors
- Jing Ding (ORCID: https://orcid.org/0000-0001-5135-4210)
- Quansheng He
- Yousheng Shu (ORCID: https://orcid.org/0000-0002-2834-2876)
- Shuyang Wang (ORCID: https://orcid.org/0000-0003-4284-9216)
- Yuling Yang
- Xin Wang (ORCID: https://orcid.org/0000-0002-6813-2371)
- Hongkun Yang
- Kexian Li (ORCID: https://orcid.org/0000-0002-1293-5538)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1111/epi.18498
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Program of Shanghai Academic Research Leader