Dynamic alterations of lymphocyte subsets following sepsis in octogenarian and elder patients
Sepsis induced a numerical reduction in lymphocytes and CD3<sup>+</sup> T-cell counts in octogenarian patients (≥80 years). The persistent decrease of CD3<sup>+</sup> T-cell counts on Day 3 and Day 7 following sepsis was associated with higher mortality in elder and octogenarian patients.<b>Trial registration</b> Chinese Clinical Trial Registry identifier: ChiCTR-ROC-17010750.
Authors
- Ran Guo (ORCID: https://orcid.org/0000-0003-0654-6314)
- Guoyu Zhao
- Wei Cheng (ORCID: https://orcid.org/0000-0002-1475-4079)
- Na Cui (ORCID: https://orcid.org/0000-0003-1128-9228)
- Dongkai Li (ORCID: https://orcid.org/0000-0002-4487-0927)
- Jiahui Zhang (ORCID: https://orcid.org/0009-0007-7234-4725)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Journal of Intensive Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1016/j.jointm.2025.04.002
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35