Decoding hippocampal subfield and glial responses in ischemia using single-cell transcriptomics
These findings highlight the diverse molecular signatures and functional differences of cells in specific hippocampal regions during global cerebral ischemia. Differences in cellular functions and composition between CA1 and CA3-DG subfields suggest that glial heterogeneity may contribute to regional differences in ischemic vulnerability. This study provides new insights into the role of glial and vascular cell populations in stroke pathology, which may inform future therapeutic strategies.
Authors
- Ji-Hyun Park (ORCID: https://orcid.org/0000-0002-4714-930X)
- Donghee Kwak
- Yun Hak Kim (ORCID: https://orcid.org/0000-0002-9796-8266)
- Hong‐Il Yoo (ORCID: https://orcid.org/0000-0002-7405-471X)
Institutions
- Johns Hopkins University (US)
- Eulji University (KR)
- Johns Hopkins Medicine (US)
- Pusan National University (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s12967-025-06738-2
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Korea Health Industry Development Institute
- National Research Foundation of Korea