Weil’s Disease with Multi-Organ Dysfunction: A Diagnostic Challenge

Leptospirosis is a zoonotic disease caused by spirochetes from the species <i>Leptospira</i> Weil's disease, the more severe manifestation of leptospirosis, is characterized by a combination of jaundice, renal injury, and hemorrhages. Diagnosing severe leptospirosis in patients with acute life-threatening multi-organ dysfunction at presentation can be challenging because of the non-specific clinical manifestations. This report describes a case of severe leptospirosis with jaundice, acute renal dysfunction, severe thrombocytopenia, pulmonary hemorrhage, and unusual manifestations, including rhabdomyolysis, acalculous cholecystitis, and pancreatitis, which required a comprehensive diagnostic evaluation of possible causes to confirm the diagnosis. The case highlights the importance of clinicians considering leptospirosis in the differential diagnosis of a patient with cryptogenic sepsis who develops multiple organ dysfunction.