Beta-blockers prolong response to androgen deprivation therapy in prostate cancer through modulation of the neuro-immuno-oncology axis
The data suggest that BB combined with ADT delay the progression to castration-resistant prostate cancer. This may be achieved by influencing androgen receptor activity, adjusting energy metabolism and fostering a pro-inflammatory antitumoral microenvironment.
Authors
- Abhilash Pandya (ORCID: https://orcid.org/0000-0002-7713-3050)
- Heidi Kristin Nielsen
- Kotryna Seip (ORCID: https://orcid.org/0000-0001-5936-7294)
- Håkon Ramberg (ORCID: https://orcid.org/0000-0002-5434-6029)
- Anna Linder (ORCID: https://orcid.org/0000-0002-9444-1346)
- Bente Lise Halvorsen (ORCID: https://orcid.org/0000-0002-6529-6485)
- Kjetil Wessel Andressen (ORCID: https://orcid.org/0000-0003-1094-1501)
- Malin Hagberg Thulin (ORCID: https://orcid.org/0000-0002-8673-1247)
- Miriam Øijordsbakken
- Gunhild Mari Mælandsmo (ORCID: https://orcid.org/0000-0002-4797-1600)
- Helene Hartvedt Grytli (ORCID: https://orcid.org/0000-0002-0618-9153)
- Matti Poutanen (ORCID: https://orcid.org/0000-0002-8953-1734)
- Shivanthe Sivanesan (ORCID: https://orcid.org/0000-0003-2089-2248)
- Kristin Austlid Taskén (ORCID: https://orcid.org/0000-0001-5530-4915)
- Betina Katz (ORCID: https://orcid.org/0009-0009-9365-2588)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Sahlgrenska University Hospital (SE)
- Artistic Realization Technologies (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1186/s12967-025-06644-7
- Citations
- 3
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Prostate Cancer Foundation
- Kreftforeningen
- Swedish Cancer Foundation
- Cancerfonden
- Stiftelsen Assar Gabrielssons Fond
- Universitetet i Oslo
- Science for Life Laboratory
- Sahlgrenska Akademin