Preclinical Evaluation of a Near-Infrared Labelled Antibody Targeting the Tumour Associated Xenoantigen N-Glycolyl-Neuraminic Acid GM3 Ganglioside
The 14F7hT-IRDye800CW probe was found to be safe and have low non-specific uptake in a model organism known to express the target. These data support future clinical development of the probe.
Authors
- Kimberly Jett (ORCID: https://orcid.org/0000-0002-3841-4562)
- Á. Casacó
- Dariέn Toledo
- Kalet León (ORCID: https://orcid.org/0000-0002-3709-7091)
- Wendy Bernhard
- C. Ronald Geyer (ORCID: https://orcid.org/0000-0003-1628-9665)
- Kris Barreto
Institutions
- Center of Molecular Immunology (Cuba) (CU)
- University of Saskatchewan (CA)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1007/s11307-025-02026-z
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Sciences and Engineering Research Council of Canada