The Cardiac and Hemodynamic Effects of Ketone Bodies Are Abnormal in Patients With Type 1 Diabetes: A Randomized Controlled Trial
The diabetic heart has reduced ketone utilization due to impaired ketolytic enzyme activity. In a randomized controlled crossover trial, we investigated whether the cardiac response to 3-hydroxybutyrate infusion is impaired in type 1 diabetes. The response on cardiac output was blunted by 80% in type 1 diabetes, with no improvement in systolic function and left ventricular work efficiency was reduced. These findings suggest impaired cardiac ketone metabolism may have clinical significance and could contribute to diabetic cardiomyopathy.
Authors
- Kristoffer Berg‐Hansen (ORCID: https://orcid.org/0000-0002-5110-0656)
- Henrik Wiggers (ORCID: https://orcid.org/0000-0002-9753-4142)
- Nikolaj Rittig (ORCID: https://orcid.org/0000-0001-9938-2181)
- Mads Svart (ORCID: https://orcid.org/0000-0002-9574-0612)
- Nigopan Gopalasingam (ORCID: https://orcid.org/0009-0006-6363-7406)
- Maj Bangshaab (ORCID: https://orcid.org/0000-0001-6265-2854)
- Niels Møller (ORCID: https://orcid.org/0000-0001-5627-7322)
- Roni Nielsen (ORCID: https://orcid.org/0000-0001-9228-3869)
Institutions
- Steno Diabetes Centers (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Diabetes
- Published
- 2025-06-17
- DOI
- https://doi.org/10.2337/db25-0243
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Hjerteforeningen
- Arvid Nilssons Fond
- Danmarks Frie Forskningsfond
- Novo Nordisk Fonden