Embedding oxygen heterocycles into BODIPY to enhance intersystem crossing for photodynamic therapy
By incorporating an oxygen heterocycle into a BODIPY core, near-infrared (NIR) absorbing dyes were successfully prepared. The solid-state structures of these systems were confirmed through X-ray crystallographic analysis. The extended BODIPY compounds exhibited absorption and emission wavelengths in the NIR region (up to <i>λ</i><sub>abs</sub> = 772 nm and <i>λ</i><sub>em</sub> = 807 nm in DMSO). Notably, the inclusion of the oxygen heterocycle enhanced intersystem crossing, enabling the newly-formed BODIPY to act as a heavy-atom-free singlet oxygen generator. Upon light-irradiation, self-assembled BODIPY nanoparticles caused mitochondrial damage by reducing the mitochondrial membrane potential, thereby promoting tumor cell apoptosis <i>in vivo</i>. Furthermore, these self-assembled nanoparticles demonstrated a significant inhibitory effect on animal tumor tissues when irradiated with an 808 nm laser.
Authors
- Zhiqiang Cui (ORCID: https://orcid.org/0009-0004-1303-6114)
- Denis Jacquemin (ORCID: https://orcid.org/0000-0002-4217-0708)
- Xin‐Dong Jiang (ORCID: https://orcid.org/0000-0002-9780-1124)
- Boris Le Guennic (ORCID: https://orcid.org/0000-0003-3013-0546)
- Gaowu W. Qin (ORCID: https://orcid.org/0000-0002-0852-6715)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Sun Xiao-hong
- Jakub Širůček (ORCID: https://orcid.org/0009-0004-9419-0411)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut Universitaire de France (FR)
- Institut des Sciences Chimiques de Rennes (FR)
- Fourth Affiliated Hospital of China Medical University (CN)
- Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation (FR)
- Shenyang University of Chemical Technology (CN)
- Université de Rennes (FR)
- China Medical University (CN)
- Nantes Université (FR)
Publication Details
- Journal
- Journal of Materials Chemistry B
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5tb00427f
- Citations
- 2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Agence Nationale de la Recherche
- National Natural Science Foundation of China