Etiology of Iridocorneal Endothelial Syndrome: Viral Infection and Immune Suppression
Our findings from multiple sequencing assays consistently indicate the absence of compelling evidence supporting viral infection in patients with ICE syndrome. Furthermore, the transcriptional analysis of ICE cells reveals a distinct profile characterized by upregulated cell growth and suppressed immune response. Future studies are necessary to validate these findings and improve the generalizability of the results.
Authors
- Yi Qu (ORCID: https://orcid.org/0000-0002-9993-8810)
- X.D. Zhang (ORCID: https://orcid.org/0009-0007-9695-7972)
- Gege Xiao
- Jing Hong (ORCID: https://orcid.org/0000-0002-8079-2073)
- Rongmei Peng (ORCID: https://orcid.org/0000-0001-9613-932X)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0003-4566-7987)
- Pei Zhang (ORCID: https://orcid.org/0000-0003-0146-1047)
- Yingyu Li (ORCID: https://orcid.org/0000-0002-9017-8894)
- Xiaozhen Liu (ORCID: https://orcid.org/0000-0001-9893-1986)
- Bowei Yuan
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Cornea
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1097/ico.0000000000003911
- Citations
- 1
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China