Identification of Therapeutic Targets in Autism Spectrum Disorder through CHD8-Notch Pathway Interaction Analysis
Our multi-level bioinformatics analysis identified key genes and regulatory networks potentially involved in ASD associated with CHD8 deficiency. These findings enhance the understanding of ASD's molecular mechanisms and highlight potential therapeutic targets, paving the way for future diagnostic and treatment strategies.
Authors
- Daiyan Jiao
- Chao Bao (ORCID: https://orcid.org/0000-0002-0982-8168)
- Hewei Zhang (ORCID: https://orcid.org/0000-0003-1784-4026)
- Dong Chen (ORCID: https://orcid.org/0000-0001-7627-9560)
- Qin Gu (ORCID: https://orcid.org/0009-0008-3300-6712)
- Shenghao Hua
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Children's Hospital of Suzhou University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1371/journal.pone.0325893
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43