Methylation aberrations and genomic instability synergistically drive the evolution of intrahepatic cholangiocarcinoma
These findings highlight the potential of DNA methylation as a biomarker for metastasis diagnosis and the interplay between local genomic instability and aberrant methylation, emphasizing their synergistic roles in driving the evolutionary trajectory of ICC.
Authors
- Youhuang Bai (ORCID: https://orcid.org/0000-0003-1347-4363)
- Guanghao Li (ORCID: https://orcid.org/0000-0001-9684-4037)
- Yong Zeng (ORCID: https://orcid.org/0000-0001-6995-8960)
- Feng Tao (ORCID: https://orcid.org/0000-0002-8259-0803)
- Tingting Hu (ORCID: https://orcid.org/0000-0003-1785-657X)
- Deqiang Sun
- Ting Wang
Institutions
- Chinese Academy of Sciences (CN)
- Sichuan University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1080/17501911.2025.2518919
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China