Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion
These findings suggest that, in mice, polypharmacy affected cardiac function and structure differently depending upon age and sex, with older males being the most affected. Further investigation may elucidate mechanisms and inform personalised medicine.
Authors
- Sarah Nicole Hilmer (ORCID: https://orcid.org/0000-0002-5970-1501)
- Gizem Gemikonakli (ORCID: https://orcid.org/0000-0003-2594-7316)
- Alexander Widiapradja (ORCID: https://orcid.org/0000-0003-3584-7722)
- John Mach (ORCID: https://orcid.org/0000-0002-6896-6376)
- Trang Tran (ORCID: https://orcid.org/0000-0002-1880-319X)
- Susan E. Howlett (ORCID: https://orcid.org/0000-0001-5351-6308)
- Matthew J. McKay (ORCID: https://orcid.org/0000-0002-3430-2467)
- Scott P. Levick (ORCID: https://orcid.org/0000-0001-5034-4942)
- Mark P. Molloy (ORCID: https://orcid.org/0000-0003-4679-5868)
- Kevin Winardi (ORCID: https://orcid.org/0009-0007-7787-8208)
Institutions
- West Virginia University (US)
- The University of Sydney (AU)
- Dalhousie University (CA)
- Hanoi Medical University (VN)
- Royal North Shore Hospital (AU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1111/bph.70082
- Citations
- 1
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 2.38