Effect of resveratrol on key signaling pathways including SIRT1/AMPK/Smad3/TGF-β and miRNA-141 related to NAFLD in an animal model
The study concluded that resveratrol has the potential to reduce liver damage from NAFLD by modulating various signaling pathways, particularly TGF-β/Smad3, SIRT1/AMPK, and miRNA-141, leading to improved lipid metabolism and reduced hepatic steatosis. While the findings underscored the multifaceted therapeutic effects of resveratrol, further research and clinical trials are necessary to fully understand its mechanisms and applications in humans.
Authors
- Esmaeel Babaeenezhad (ORCID: https://orcid.org/0000-0003-2549-7802)
- Zeynab Yousefi (ORCID: https://orcid.org/0000-0002-7931-5456)
- Mehdi Koushki (ORCID: https://orcid.org/0000-0003-0071-3505)
- Navid Farahmandian (ORCID: https://orcid.org/0000-0002-4596-7157)
- Yaser Mohammadi (ORCID: https://orcid.org/0000-0003-1819-853X)
- Mohammadjavad Sotoudeheian (ORCID: https://orcid.org/0000-0001-7181-2944)
- Soudabeh Fallah
- Sahar Yarahmadi (ORCID: https://orcid.org/0000-0002-8171-1650)
Institutions
- Zanjan University of Medical Sciences (IR)
- Iran University of Medical Sciences (IR)
- Lorestan University of Medical Sciences (IR)
Publication Details
- Journal
- Research in Pharmaceutical Sciences
- Published
- 2025-05-01
- DOI
- https://doi.org/10.4103/rps.rps_220_24
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 3.67