Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study
© 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Authors
- Anjum Misbahuddin
- Raquel Real (ORCID: https://orcid.org/0000-0001-8117-742X)
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Marte Theilmann Jensen (ORCID: https://orcid.org/0000-0002-3727-9477)
- Riona Fumi (ORCID: https://orcid.org/0009-0007-4917-6559)
- Bradley R. Groveman (ORCID: https://orcid.org/0000-0002-5059-7672)
- Thomas T. Warner (ORCID: https://orcid.org/0000-0001-6195-6995)
- Byron Caughey (ORCID: https://orcid.org/0000-0002-3928-6101)
- Lesley Wu (ORCID: https://orcid.org/0000-0001-5464-5603)
- Andrew G. Hughson (ORCID: https://orcid.org/0000-0002-0725-4017)
- Megan Hodgson
- Stefanie Lerche (ORCID: https://orcid.org/0000-0002-5508-004X)
- Nirosen Vijiaratnam (ORCID: https://orcid.org/0000-0002-9671-0212)
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Thomas Foltynie (ORCID: https://orcid.org/0000-0003-0752-1813)
- David Vaughan (ORCID: https://orcid.org/0000-0001-7303-6416)
- Annelies Quaegebeur (ORCID: https://orcid.org/0000-0001-5357-9341)
- Christina D. Orrú (ORCID: https://orcid.org/0000-0001-7253-2944)
- Edwin Jabbari (ORCID: https://orcid.org/0000-0001-6844-882X)
- P. Nigel Leigh (ORCID: https://orcid.org/0000-0002-6702-0378)
- Alejandro Martínez-Carrasco (ORCID: https://orcid.org/0000-0001-6191-1703)
- Eleanor J. Stafford (ORCID: https://orcid.org/0000-0003-2451-4308)
- Zane Jaunmuktane (ORCID: https://orcid.org/0000-0001-7738-8881)
- Christine Girges (ORCID: https://orcid.org/0000-0001-5019-6812)
- Kieren Allinson (ORCID: https://orcid.org/0000-0003-3468-2110)
- Alistair Church
- Christopher Kobylecki
- Isabel Wurster (ORCID: https://orcid.org/0000-0003-0157-5722)
- Huw R. Morris (ORCID: https://orcid.org/0000-0002-5473-3774)
- Olaf Ansorge (ORCID: https://orcid.org/0000-0003-1825-5434)
- Ana-Luisa Gil-Martinez
- Boyd Ghosh (ORCID: https://orcid.org/0000-0001-5887-9220)
- Kailash P. Bhatia (ORCID: https://orcid.org/0000-0001-8185-286X)
Institutions
- Brighton and Sussex Medical School (GB)
- Queen Mary University of London (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Royal Gwent Hospital (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- Queen's Hospital (GB)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Hertie Institute for Clinical Brain Research (DE)
- Office of Extramural Research (US)
- University College London (GB)
Publication Details
- Journal
- The Lancet Neurology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1016/s1474-4422(25)00157-7
- Citations
- 21
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 29.17
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Van Andel Research Institute
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- CurePSP
- Jazz Pharmaceuticals
- PSP Association
- UK Research and Innovation
- Neurocrine Biosciences
- Verily Life Sciences
- Voyager Therapeutics
- National Institute for Health and Care Research
- Department of Health and Social Care
- Parkinson's UK
- Rosetrees Trust
- Servier
- H. Lundbeck A/S
- Sun Pharma
- Genentech
- Allergan
- Avid Radiopharmaceuticals
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research