Minocycline treatment reduces the activation of mononuclear phagocytes and improves retinal function in a mouse model of Leber congenital amaurosis
Our data indicates that MP migration into the subretina is associated with retinal degeneration in RPE65/rd12 mice. Inhibiting MP migration into the subretina was associated with improved retinal function. These findings may guide the development of therapies targeting MP activation for neuroprotection in LCA and potentially other retinoid cycle-related retinal degeneration blinding diseases.
Authors
- Ettel Bubis
- Estela Derzane
- Hadas Ketter-Katz
- Florian Sennlaub (ORCID: https://orcid.org/0000-0003-4412-1341)
- Ygal Rotenstreich (ORCID: https://orcid.org/0000-0003-2366-1779)
- Ifat Sher (ORCID: https://orcid.org/0000-0003-0859-6606)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Tel Aviv University (IL)
- Université Paris Cité (FR)
- Sheba Medical Center (IL)
- Sorbonne Université (FR)
Publication Details
- Journal
- Graefe s Archive for Clinical and Experimental Ophthalmology
- Published
- 2025-06-18
- DOI
- https://doi.org/10.1007/s00417-025-06768-y
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tel Aviv University