Risk of ischemic stroke associated with anti-rheumatic agents in patients with rheumatoid arthritis: A nationwide population-based case-control study
In this nationwide cohort study of patients with RA, treatment with sulfasalazine and hydroxychloroquine was associated with a decreased risk of stroke, while glucocorticoids and tocilizumab were linked to an increased risk of stroke. The association of tocilizumab with stroke should be cautiously interpreted due to the statistical limitations.
Authors
- Yong‐Gil Kim (ORCID: https://orcid.org/0000-0002-8029-7355)
- Bin Yoo (ORCID: https://orcid.org/0000-0002-1836-5273)
- Seon‐Ok Kim (ORCID: https://orcid.org/0000-0001-9010-5460)
- Chang‐Keun Lee (ORCID: https://orcid.org/0000-0003-3653-7515)
- Ji Seon Oh (ORCID: https://orcid.org/0000-0002-0205-6492)
- Ye‐Jee Kim (ORCID: https://orcid.org/0000-0002-3307-2970)
- Soo Min Ahn (ORCID: https://orcid.org/0000-0002-9213-9768)
- Seokchan Hong (ORCID: https://orcid.org/0000-0001-8722-3124)
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1371/journal.pone.0326311
- Citations
- 2
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Korea Health Industry Development Institute
- Asan Institute for Life Sciences, Asan Medical Center