Palladium-catalysed carbonylation of aryl diazonium salts to access bioconjugation-ready esters
We report a palladium-catalyzed esterification protocol using aryl diazonium salts and <i>N</i>-hydroxysuccinimidyl (NHS) formate as a CO surrogate, avoiding the use of toxic CO gas. This mild and efficient method employs readily available starting materials and affords NHS esters suitable for late-stage functionalization and bioconjugation applications.
Authors
- Jyotirmayee Dash (ORCID: https://orcid.org/0000-0003-4130-2841)
- Pratap Paul
Institutions
- Indian Association for the Cultivation of Science (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02739j
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Indian Council of Medical Research
- Science and Engineering Research Board