The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy
Rifaximin and lactulose may enhance cognitive performance in MHE rats by modulating gut microbiota metabolism and preserving the intestinal barrier integrity. This modulation is associated with lowered ammonia levels, decreased translocation of LPS to the liver, and reduced inflammatory response, both in the liver and systemically.
Authors
- Xueyan Lin (ORCID: https://orcid.org/0000-0003-1399-7674)
- Shiyun Lu (ORCID: https://orcid.org/0000-0002-1615-1036)
- Rongrong Chen (ORCID: https://orcid.org/0009-0001-9646-0938)
- Zhengchao Zhang (ORCID: https://orcid.org/0000-0003-3291-2947)
- Yi Lin (ORCID: https://orcid.org/0000-0002-7635-2518)
Institutions
- Fujian Medical University (CN)
- Fuzhou Second Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1371/journal.pone.0325988
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Technology Project