Cold atmospheric plasma combined with nanoparticles in cancer therapy

Abstract This review explores the application of cold atmospheric plasma (CAP) and nanoparticles (NPs) in cancer therapy, highlighting their potential to enhance treatment efficacy and minimize side effects. CAP generates reactive oxygen and nitrogen species that selectively induce apoptosis in cancer cells, while NPs improve drug delivery, enhance targeting precision, and reduce adverse effects on healthy tissues. By summarizing various types of NPs, including gold, silver, magnetic, and other NPs, we evaluate their individual and combined effects with CAP across different cancer models. Our findings suggest that combined CAP‐NPs significantly enhance therapeutic outcomes by increasing cancer cell sensitivity and minimizing damage to surrounding tissues. This synergistic approach not only aligns with previous research on CAP's selective toxicity but also reveals new possibilities for optimizing cancer treatment through targeted NP delivery. Further clinical research is needed to establish the safety and efficacy of this combination, paving the way for novel, patient‐specific treatment strategies with improved outcomes.