Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of <i>Acinetobacter baumannii</i> MAR13-1452 (K125) Capsular Polysaccharide for Vaccine Development
<i>Acinetobacter baumannii</i> is a highly drug-resistant pathogen that causes severe hospital infections and urgently requires new treatment strategies. Surface-exposed glycans of these bacteria have emerged as promising vaccine targets due to their immunogenic potential. Here, we report the first total synthesis of the tetrasaccharide repeating unit of <i>Acinetobacter baumannii</i> MAR13-1452 (K125). The presence of rare deoxy amino sugars and the exclusive 1,2-<i>cis</i> glycosidic linkages within the tetrasaccharide make its synthesis more challenging. A one-pot oligosaccharide assembly enabled efficient and facile synthesis of the target molecule.
Authors
- Yongmei Yin (ORCID: https://orcid.org/0000-0001-6698-9681)
- Zhen-Hua Dang
- Xingxing Kang
- Haoyu Xue
- Yu Zhou (ORCID: https://orcid.org/0000-0003-4742-3150)
- Xianwei Ding
- Hongzhen Jin
- Ke Feng (ORCID: https://orcid.org/0009-0006-5514-6818)
- Jia Tian (ORCID: https://orcid.org/0009-0005-8783-8571)
- Wei Guang Zhao (ORCID: https://orcid.org/0000-0002-7887-2357)
Institutions
- Qingdao University (CN)
- Nankai University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- State Key Laboratory of Chemical Engineering (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1021/acs.orglett.5c02016
- Citations
- 2
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Tianjin Science and Technology Program