Green synthesis of Ce3+ doped V2O5 NPs as an advanced electrode material for possible supercapacitor and therapeutic applications

• Un-doped and (1–5 mol%) Ce 3+ doped V 2 O 5 nanoparticles were synthesized using a combustion method. • The optimized V 2 O 5 :5Ce³⁺ electrode showed a specific capacitance of 180.47 F/g, retained 94.31% capacitance after 5000 cycles. • V₂O₅:5Ce 3+ displayed strong antioxidant activity by scavenging DPPH and H₂O₂ radicals and normalizing oxidative stress markers in NaNO 2 induced models. • The NPs were biocompatible with RBCs, effectively prevented hemolysis, and inhibited ADP-induced platelet aggregation by 65.30%. A series of un-doped and (1-5 mol %) Ce³⁺ doped V 2 O 5 nanoparticles (NPs) are synthesized to enhance their electrochemical and biological properties. V 2 O 5 is a promising material for energy storage, but its performance can be improved through doping. Additionally, its potential biomedical applications, particularly in oxidative stress management and thrombosis prevention, are explored. A simple, eco-friendly green combustion method is used for the synthesis of Ce 3+ doped V 2 O 5 (1-5 mol %). Structural, morphological, and compositional characteristics are analyzed using PXRD, FE-SEM, TEM, XPS and UV-Vis. Electrochemical performance is evaluated in a 3 M KOH electrolyte, while biological activities, including antioxidant, hemocompatibility, and antiplatelet effects, are assessed through various assays. V₂O₅:5Ce 3+ exhibited a high surface area (653.76 m 2 /g), superior specific capacitance ( C sp ) 180.47 F/g and excellent cycling stability (94.31% retention after 5000 cycles). Biologically, it showed strong antioxidant activity, RBC hemolysis protection, and 65.30 % platelet aggregation inhibition, making it a multifunctional material for energy storage and biomedical applications.