Cell-Free DNA Comprises the Strand-Specific Characteristic Associated with Transcription and Methylation
As a proof-of-concept, we demonstrated the existence of a cfDNA strand-specific characteristic, which reflects footprint signatures including transcription and methylation. This study provides insights into the biological properties of cfDNA and a potential novel role as biomarkers.
Authors
- Lingguo Li (ORCID: https://orcid.org/0000-0003-0046-5951)
- Changlin Yang (ORCID: https://orcid.org/0000-0001-5687-600X)
- Haiqiang Zhang (ORCID: https://orcid.org/0000-0001-8757-4549)
- Xin Jin (ORCID: https://orcid.org/0000-0001-7554-4975)
- Wei Chen (ORCID: https://orcid.org/0000-0002-8087-7077)
- Xinxin Wang
- Yan Zhang (ORCID: https://orcid.org/0000-0003-2281-7807)
- Jianhua Yin (ORCID: https://orcid.org/0000-0002-1840-3938)
- Jinjin Xu (ORCID: https://orcid.org/0000-0002-9398-252X)
- Wenwen Zhou (ORCID: https://orcid.org/0000-0003-2596-1388)
- Yeqin Wang (ORCID: https://orcid.org/0000-0002-3841-2129)
- Rijing Ou
- Guodan Zeng (ORCID: https://orcid.org/0000-0001-5438-0932)
Institutions
- Botswana Geoscience Institute (BW)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1093/clinchem/hvaf070
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China