Analysis of Hyperexpanded T Cell Clones in <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 Vaccine‐Associated Liver Injury by Spatial Proteomics and Transcriptomics
Spatial proteomics and spatial transcriptomics techniques allowed the localisation and characterisation of hyperexpanded CD8+ T cell clones at single cell level. They exhibited cytotoxic and tissue-resident memory properties, suggesting their involvement in the pathogenesis of SVALI.
Authors
- Carl Zinner (ORCID: https://orcid.org/0000-0003-1609-0920)
- Ewelina Magdalena Bartoszek (ORCID: https://orcid.org/0000-0001-5153-9258)
- Asmita Pant (ORCID: https://orcid.org/0000-0003-4468-8639)
- Matthias S. Matter (ORCID: https://orcid.org/0000-0002-2005-5266)
- Sarp Uzun (ORCID: https://orcid.org/0000-0003-0873-0457)
- Neşe Karadağ Soylu (ORCID: https://orcid.org/0000-0002-6303-5484)
- Cumali Efe (ORCID: https://orcid.org/0000-0001-6593-5702)
- Paul Gueguen (ORCID: https://orcid.org/0000-0003-2930-6073)
- Hélène Heusler
- Sandra M. Frei
- Benedetta Terziroli Beretta‐Piccoli
- Ilaria Arborelli
Institutions
- King's College London (GB)
- University of Basel (CH)
- University of Zurich (CH)
- University Hospital of Basel (CH)
- ETH Zurich (CH)
- Ospedale regionale di Lugano (CH)
- Ente Ospedaliero Cantonale (CH)
- Sağlık Bilimleri Üniversitesi (TR)
- King's College Hospital (GB)
- Università della Svizzera italiana (CH)
- Harran University (TR)
Publication Details
- Journal
- Liver International
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1111/liv.70172
- Citations
- 7
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 9.77
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Botnar Research Centre for Child Health, University of Basel