<i>Calcium homeostasis modulator 2</i> aggravates <i>α-synuclein</i>-induced neurotoxicity in Parkinson’s disease by activating <i>PARP-1</i> depended Parthanatos
Calhm2 repression lightened α-Syn aggregation-induced neurotoxicity and PARP-1-dependent Parthanatos in PD, providing a novel therapeutic target for PD treatment.
Authors
- Zongyu Xiao (ORCID: https://orcid.org/0000-0002-3678-1086)
- Yiying Li (ORCID: https://orcid.org/0000-0003-3566-6008)
- Huaming Zhang (ORCID: https://orcid.org/0000-0003-3189-3190)
- Huanjun Xu (ORCID: https://orcid.org/0000-0002-2704-5108)
- Guanghao Liu (ORCID: https://orcid.org/0000-0001-8386-5410)
- Qi Pan (ORCID: https://orcid.org/0000-0001-8542-0925)
Institutions
- Sun Yat-sen University (CN)
- Soochow University (CN)
- Qiongtai Teachers College (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Human Molecular Genetics
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1093/hmg/ddaf091
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78