Hypothyroidism and Schizophrenia: Causal Link and Therapeutic Challenge – A Case Report

Schizophrenia is a chronic disabling psychosis characterized by thought disorganization, positive symptoms such as hallucinations and delusions, and negative symptoms including apathy and social withdrawal. Among the many pathophysiological hypotheses proposed, endocrine disturbances—particularly thyroid dysfunction—have attracted increasing attention. We report the case of a 28-year-old man with schizophrenia in whom a severe hypothyroidism was diagnosed during the course of illness. This case highlights important clinical considerations regarding the interaction between these two conditions and their therapeutic implications. Based on this observation and a comprehensive literature review, we explore the possible pathophysiological links, the iatrogenic impact of antipsychotic treatments on thyroid function, and propose adapted therapeutic strategies for managing this dual pathology. Keywords: Schizophrenia, hypothyroidism, antipsychotics, autoimmunity, hormone replacement therapy, thyroid dysfunction.