Systemic Lupus Erythematosus

1.ABSRTACT Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. 2.INTRODUCTION Systemic Lupus Erythematosus(SLE) is an auto immune connective tissue disease. This disease occurs with specific antinuclear antibodies. SLE is recognized as one of the most prominent rheumatic diseases and it is a multi-system autoimmune syndrome. Many studies found that the interaction between aquired factors and congenital factors responsible for excessive production of autoantibodies. These autoantibodies react with autoantigens forming immune complexes, with in the human body. Such immune complexes effects various organs like joints, skin, blood vessels, etc., resulting in multi-system damage or we can say multi-organ dysfunction. Also the cytokine dysregulation( especially type 1 interferon) and impaired clearance of dead cells leads to cause SLE.